Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929985 | 0.90 | HTT (0.70) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| Ethylene SCHEMBL8379177 | 0.87 | HTT (0.66) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL3456196 | 0.83 | HPGD (1.00) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL10722320 | 0.81 | HTT (0.89) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL13618523 | 0.79 | HSP90AA1 (0.51) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL30530619 | 0.78 | HTT (0.89) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL13162411 | 0.78 | HTT (0.96) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL1520613 | 0.78 | HTT (0.89) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL5953644 | 0.77 | CDK4 (0.65) | HTTALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL14825166 | 0.76 | HTT (1.00) | HTTALDH1A1CYP2C9CYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140467-A1 | OXOBENZINDOLIZINOQUINOLINES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2009-11-19 | — | — | WO | disclosed |