Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.57 |
| ▸ | BRAF | P15056 | 19/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | PAK3 | O75914 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893834 | 0.90 | RAF1 (0.71) | RAF1BRAFLCKFYNPDGFRB | |
| SCHEMBL13618571 | 0.90 | BRAF (0.55) | RAF1BRAFLCKFYNPDGFRB | |
| SCHEMBL2895281 | 0.81 | BRAF (0.67) | RAF1BRAFKDR | |
| SCHEMBL13838889 | 0.80 | RAF1 (0.66) | RAF1BRAFKDR | |
| SCHEMBL13838887 | 0.80 | RAF1 (0.57) | RAF1BRAFLCKFYNPDGFRB | |
| SCHEMBL13211150 | 0.80 | RAF1 (0.57) | RAF1BRAFLCKFYNPDGFRB | |
| SCHEMBL2893951 | 0.80 | P2RX3 (0.63) | RAF1BRAFKDR | |
| SCHEMBL2901751 | 0.80 | RAF1 (0.71) | RAF1BRAFKDR | |
| SCHEMBL13618558 | 0.79 | BRAF (0.70) | RAF1BRAFLCKFYNPDGFRB | |
| SCHEMBL2886102 | 0.79 | RAF1 (0.64) | RAF1BRAFLCKFYNPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |