Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PARG | Q86W56 | 1/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | TYMS | P04818 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13030213 | 0.82 | KDM4E (0.54) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL7263029 | 0.80 | KDM4E (0.66) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL29535139 | 0.80 | KDM4E (0.66) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL18020459 | 0.78 | IP6K1 (0.52) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL16232298 | 0.77 | KDM4E (0.59) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL27812566 | 0.77 | KDM4E (0.55) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL31463101 | 0.77 | TYMS (0.72) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL5313776 | 0.77 | TYMS (0.72) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL6014177 | 0.77 | TYMS (0.72) | KDM4EHSD17B10LMNAPARP1TNKS2 | |
| SCHEMBL29900526 | 0.77 | TYMS (0.72) | KDM4EHSD17B10LMNAPARP1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143049-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |