Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.72 |
| ▸ | KDR | P35968 | 11/20 | 0.72 |
| ▸ | CSF1R | P07333 | 8/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.72 |
| ▸ | STK3 | Q13188 | 9/20 | 0.70 |
| ▸ | MAP4K5 | Q9Y4K4 | 9/20 | 0.70 |
| ▸ | RET | P07949 | 8/20 | 0.70 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.70 |
| ▸ | FLT1 | P17948 | 6/20 | 0.70 |
| ▸ | EGFR | P00533 | 11/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.69 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 9/20 | 0.67 |
| ▸ | TAOK1 | Q7L7X3 | 7/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.67 |
| ▸ | FYN | P06241 | 5/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363370 | 0.90 | EGFR (0.78) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1362333 | 0.90 | IGF1R (0.77) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1362281 | 0.89 | IGF1R (0.84) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1363453 | 0.88 | IGF1R (0.73) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1361854 | 0.87 | IGF1R (0.78) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1362518 | 0.87 | IGF1R (0.80) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1361389 | 0.86 | IGF1R (0.82) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1363465 | 0.86 | IGF1R (0.82) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1361315 | 0.84 | IGF1R (0.82) | IGF1RKDRCSF1RPTK2STK3 | |
| SCHEMBL1364210 | 0.84 | IGF1R (0.82) | IGF1RKDRCSF1RPTK2STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067409-B2 | Protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | claimed |
| US-8067409-B2 | Protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| EP-2222682-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090253723-A1 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | US | disclosed |
| WO-2009070516-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253723-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | IGF1R 1941/4885KDR 1617/4885CSF1R 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.