PHKG1

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform · Q16816 · PHKG1 on Sugi Atlas →

2,823 patent compounds predicted against PHKG1, 2,633 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL8321621)	1.00	3/20
SCHEMBL8323028	1.00	3/20
Hydrochloric Acid (SCHEMBL8323337)	1.00	3/20
Hydrochloric Acid (SCHEMBL8323340)	1.00	3/20
Hydrochloric Acid (SCHEMBL8323341)	1.00	3/20
SCHEMBL8325893	1.00	3/20
SCHEMBL8325899	1.00	3/20
SCHEMBL8325901	1.00	3/20
SCHEMBL8325755	0.84	3/20
SCHEMBL8325756	0.84	3/20
SCHEMBL8325761	0.84	3/20
SCHEMBL8328590	0.84	3/20
Hydrochloric Acid (SCHEMBL8325486)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325487)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325673)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325674)	0.83	3/20
Hydrochloric Acid (SCHEMBL8322489)	0.81	3/20
Hydrochloric Acid (SCHEMBL8326455)	0.81	3/20
Hydrochloric Acid (SCHEMBL8326458)	0.81	3/20
Hydrochloric Acid (SCHEMBL8324847)	0.79	3/20

Clinical trials — most relevant to PHKG1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Study in Adult Ph-positive ALL	PHASE2	UNKNOWN
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients	PHASE2	COMPLETED
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer	PHASE1/PHASE2	RECRUITING
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Biological Effects of Quercetin in COPD Phase II	PHASE2	UNKNOWN
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
GSD VI and GSD IX Natural History	nan	RECRUITING
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED
'Glycogen Storage Diseases (GSDs) in Indian Children- Establishing an Indian GSD (I-GSD) Registry'	nan	RECRUITING
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.	nan	NOT_YET_RECRUITING
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans: A Pilot Study	nan	WITHDRAWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA	nan	RECRUITING
Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors	nan	UNKNOWN
Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia	nan	UNKNOWN
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PHKG1 binder may also engage these)

Protein	Name	Similarity
P07934	—	1.000	P07934 →
P00518	—	1.000	P00518 →
P13286	—	1.000	P13286 →
PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0.999	landscape →
Q9DB30	—	0.996	Q9DB30 →
P31325	—	0.994	P31325 →
Q2KJ16	—	0.994	Q2KJ16 →
Q8VZD5	—	0.994	Q8VZD5 →
Q755C4	—	0.994	Q755C4 →
P51138	—	0.993	P51138 →
O08875	—	0.992	O08875 →
Q8BHI9	—	0.992	Q8BHI9 →
Q66JF3	—	0.992	Q66JF3 →
Q62074	—	0.992	Q62074 →
Q02956	—	0.992	Q02956 →
Q19266	—	0.992	Q19266 →
P51137	—	0.992	P51137 →
Q90XF2	—	0.991	Q90XF2 →
NIM1K	Serine/threonine-protein kinase NIM1	0.991	landscape →
Q66I46	—	0.991	Q66I46 →
Q9U2Q9	—	0.991	Q9U2Q9 →
Q6PFQ0	—	0.991	Q6PFQ0 →
P43288	—	0.991	P43288 →
Q40518	—	0.991	Q40518 →
Q501V0	—	0.991	Q501V0 →
F1M7Y5	—	0.991	F1M7Y5 →
P43289	—	0.991	P43289 →
PRKCZ	Protein kinase C zeta type	0.991	landscape →
Q64682	—	0.991	Q64682 →
A8WUG4	—	0.990	A8WUG4 →