Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 4/20 | 0.40 |
| ▸ | CHUK | O15111 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15219253 | 0.80 | IKBKB (0.42) | PIM1PIM3PIM2IKBKBCHUK | |
| SCHEMBL5585177 | 0.76 | KDM4E (0.42) | PIM1PIM3PIM2IKBKBCHUK | |
| SCHEMBL30775218 | 0.76 | CHRNB2 (0.41) | PIM1CHUKROCK1PRKCZDYRK1A | |
| SCHEMBL31080418 | 0.76 | CHEK1 (0.40) | PIM1PIM3PIM2IKBKBACVR1B | |
| SCHEMBL11919289 | 0.76 | PIM1 (0.40) | PIM1PIM3PIM2IKBKBCHUK | |
| SCHEMBL11916054 | 0.76 | PIM1 (0.42) | PIM1PIM3PIM2IKBKBCHUK | |
| SCHEMBL31080802 | 0.75 | IGF1R (0.43) | PIM1PIM3PIM2IKBKBDYRK1A | |
| SCHEMBL30775314 | 0.74 | CHRM1 (0.40) | PIM1CHUKROCK1PRKCZDYRK1A | |
| SCHEMBL31080170 | 0.73 | IGF1R (0.42) | PIM1PIM3PIM2 | |
| SCHEMBL28527069 | 0.72 | LPAR1 (0.34) | PIM1PIM3PIM2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143389-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |