Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 5/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809581 | 0.94 | ABHD6 (0.67) | ABHD6PIK3CAMTORHDAC1NAMPT | |
| SCHEMBL3873145 | 0.91 | ABHD6 (0.65) | ABHD6HDAC1NAMPTGPR119ESR2 | |
| SCHEMBL31070584 | 0.90 | ABHD6 (0.64) | ABHD6HDAC1NAMPTGPR119ESR2 | |
| SCHEMBL38652842 | 0.88 | ABHD6 (0.62) | ABHD6HDAC1NAMPTGPR119ESR2 | |
| SCHEMBL15000510 | 0.86 | ESR2 (0.65) | ABHD6PIK3CAMTORHDAC1NAMPT | |
| SCHEMBL1010120 | 0.86 | NR1H2 (0.63) | ABHD6PIK3CAMTORHDAC1NAMPT | |
| SCHEMBL383293 | 0.82 | TMEM97 (0.62) | ABHD6HDAC1NAMPTGPR119ESR2 | |
| SCHEMBL25407569 | 0.81 | ESR2 (0.67) | ABHD6HDAC1NAMPTGPR119ESR2 | |
| SCHEMBL30593262 | 0.81 | ESR2 (0.67) | ABHD6HDAC1NAMPTGPR119ESR2 | |
| SCHEMBL14959464 | 0.81 | ABHD6 (0.68) | ABHD6SMN1; SMN2AOC3SLC6A9HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848694-B1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | HOFFMANN LA ROCHE (CH) | 2009-11-25 | — | — | EP | disclosed |