Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.60 |
| ▸ | NPC1 | O15118 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 9/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 3/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251620 | 0.89 | RAB9A (0.77) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL9050226 | 0.79 | RAB9A (0.84) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL15425049 | 0.77 | MAPT (0.54) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL15425050 | 0.77 | NPC1 (0.64) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL1181434 | 0.76 | RAB9A (1.00) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL2089082 | 0.76 | DYRK1A (0.77) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL1181118 | 0.74 | RAB9A (0.77) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL22307585 | 0.74 | RAB9A (0.81) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL14910131 | 0.73 | NPC1 (0.51) | RAB9ANPC1MAPTMAPK1MEN1 | |
| SCHEMBL1608353 | 0.72 | MAPT (0.63) | RAB9ANPC1MAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140342-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2009-11-19 | — | — | WO | disclosed |