Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 11/20 | 0.79 |
| ▸ | HPRT1 | P00492 | 8/20 | 0.72 |
| ▸ | POLG | P54098 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | EDNRA | P25101 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | HBB | P68871 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | VCP | P55072 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11308931 | 0.91 | PNP (0.88) | PNPHPRT1POLGBLMUSP2 | |
| SCHEMBL11313321 | 0.90 | PNP (0.86) | PNPHPRT1POLGBLMUSP2 | |
| Ammonia Solution, Strong SCHEMBL11310327 | 0.90 | PNP (0.86) | PNPHPRT1POLGBLMUSP2 | |
| SCHEMBL11327665 | 0.90 | PNP (0.86) | PNPHPRT1POLGBLMUSP2 | |
| SCHEMBL8050648 | 0.87 | PNP (0.65) | PNPHPRT1POLGBLMUSP2 | |
| SCHEMBL13707332 | 0.86 | BLM (0.78) | PNPHPRT1POLGBLMUSP2 | |
| SCHEMBL24940649 | 0.86 | PNP (0.80) | PNPHPRT1POLGPOLB | |
| Acyclovir Diphosphate SCHEMBL9472121 | 0.85 | PNP (1.00) | PNPHPRT1POLGBLMUSP2 | |
| Acyclovir SCHEMBL145606 | 0.85 | PNP (0.91) | PNPHPRT1POLGBLMUSP2 | |
| Acyclovir SCHEMBL543440 | 0.85 | PNP (0.91) | PNPHPRT1POLGBLMUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |