Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12847195 | 0.88 | AXL (0.56) | AXLGAASMN1; SMN2KMT2APOLB | |
| SCHEMBL11718960 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTPDE3BPDE3APDE4A | |
| SCHEMBL764744 | 0.70 | AXL (0.56) | AXLSMN1; SMN2KMT2AMAPTPDE3B | |
| SCHEMBL2375581 | 0.66 | AXL (1.00) | AXLSMN1; SMN2KMT2AMAPTPDE3B | |
| SCHEMBL7582370 | 0.66 | AXL (0.46) | AXLGAAKMT2AMAPTHTT | |
| SCHEMBL5566954 | 0.65 | AXL (0.69) | AXLSMN1; SMN2MAPTPDE3BPDE3A | |
| SCHEMBL4864133 | 0.65 | PDE4B (0.52) | AXLGAAKMT2APOLBPDE3B | |
| SCHEMBL5561070 | 0.63 | AXL (0.67) | AXLSMN1; SMN2KMT2APOLBMAPT | |
| SCHEMBL11846026 | 0.63 | AXL (0.92) | AXLSMN1; SMN2MAPTPDE3BPDE3A | |
| SCHEMBL20279531 | 0.63 | AXL (0.67) | AXLGAASMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140342-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2009-11-19 | — | — | WO | disclosed |