Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | USP1 | O94782 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270517 | 0.91 | JAK2 (0.47) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL13608332 | 0.88 | JAK2 (0.46) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL12371651 | 0.87 | JAK2 (0.45) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL13608206 | 0.85 | GRIN1 (0.44) | JAK2JAK3USP1GRIN1GRIN2B | |
| SCHEMBL13608238 | 0.85 | JAK2 (0.45) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL12371654 | 0.83 | JAK2 (0.39) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL12371660 | 0.82 | PRKCQ (0.46) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL12371665 | 0.82 | JAK2 (0.51) | JAK2JAK3USP1TLR7 | |
| SCHEMBL13608336 | 0.81 | PIK3CD (0.42) | JAK2JAK3USP1EGFRFGFR1 | |
| SCHEMBL12371668 | 0.81 | JAK2 (0.45) | JAK2JAK3USP1EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | JAK2 1072/4885JAK3 1062/4885USP1 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.