SCHEMBL13620475

SCHEMBL13620475

Cc1cccc(F)c1C(=O)NC(=O)Nc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
MAPT P10636 2/20 0.47
USP2 O75604 1/20 0.47
ALOX15 P16050 1/20 0.47
TLR7 Q9NYK1 2/20 0.46
BRAF P15056 11/20 0.45
KDR P35968 3/20 0.44
MAPK14 Q16539 1/20 0.44
TNNI3K Q59H18 1/20 0.44
FFAR1 O14842 1/20 0.42
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
AURKA O14965 1/20 0.42
PDGFRB P09619 1/20 0.42
KIT P10721 1/20 0.42
PDGFRA P16234 1/20 0.42
FLT1 P17948 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flufenoxuron SCHEMBL27798 0.94 MEN1 (0.52) TLR8MEN1KMT2AMAPTUSP2
Flufenoxuron SCHEMBL8407576 0.94 MEN1 (0.52) TLR8MEN1KMT2AMAPTUSP2
Flufenoxuron SCHEMBL29413952 0.94 MEN1 (0.52) TLR8MEN1KMT2AMAPTUSP2
SCHEMBL9325616 0.92 MEN1 (0.51) TLR8MEN1KMT2AMAPTUSP2
Flufenoxuron SCHEMBL28899111 0.91 MEN1 (0.50) TLR8MEN1KMT2AMAPTUSP2
Flufenoxuron SCHEMBL8352196 0.89 MEN1 (0.48) TLR8MEN1KMT2AMAPTUSP2
Flufenoxuron SCHEMBL9274900 0.88 TLR8 (0.52) TLR8MEN1KMT2AMAPTUSP2
SCHEMBL10338942 0.86 BRAF (0.46) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL31499167 0.86 TLR8 (0.51) TLR8MEN1KMT2AMAPTUSP2
SCHEMBL10339846 0.84 TLR8 (0.49) TLR8MEN1KMT2AMAPTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009133181-A1 ETHER-AMIDE TYPE COMPOUNDS, PREPARATION METHOD AND USES RHODIA OPERATIONS (FR) 2009-11-05 WO disclosed
WO-2009092795-A1 USE OF ESTER AMIDES AS SOLVENTS, ESTER AMIDES AS SUCH, AND METHOD FOR PREPARING ESTER AMIDES RHODIA OPERATIONS (FR) 2009-07-30 WO disclosed