Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559609 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL6468123 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL13315465 | 0.81 | ALDH1A1 (0.47) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL10069358 | 0.81 | ALDH1A1 (0.43) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL10069380 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL2556818 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL2558486 | 0.78 | NPC1 (0.44) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL1055010 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL26216592 | 0.77 | TDP1 (0.47) | KDM4EALDH1A1RAB9ANPC1TDP1 | |
| SCHEMBL30888677 | 0.76 | ALDH1A1 (0.38) | KDM4EALDH1A1RAB9ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638961-B1 | HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-18 | — | — | EP | disclosed |