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SCHEMBL13620662

SCHEMBL13620662

O=C(O)CNC(=O)c1c2ncn(Cc3ccccc3)c2cc2c1ncn2Cc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ EGLN3 Q9H6Z9 3/20 1.00
▸ EGLN1 Q9GZT9 10/20 0.67
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ LMNA P02545 1/20 0.46
▸ MEN1 O00255 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ CYP1A2 P05177 1/20 0.45
▸ POLB P06746 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13620538 0.88 EGLN3 (0.78) EGLN3EGLN1ALDH1A1HPGDKMT2A
SCHEMBL1080241 0.88 EGLN3 (1.00) EGLN3EGLN1L3MBTL1
SCHEMBL1079849 0.87 EGLN3 (0.77) EGLN3EGLN1
SCHEMBL1080932 0.86 EGLN3 (0.75) EGLN3EGLN1
SCHEMBL1081707 0.85 EGLN3 (0.74) EGLN3EGLN1L3MBTL1LMNAMEN1
SCHEMBL1081618 0.85 EGLN3 (0.76) EGLN3EGLN1L3MBTL1LMNAMEN1
SCHEMBL1080635 0.83 EGLN3 (0.71) EGLN3EGLN1L3MBTL1
SCHEMBL13620540 0.82 EGLN3 (0.69) EGLN3EGLN1L3MBTL1
SCHEMBL1081805 0.81 EGLN1 (0.69) EGLN3EGLN1
SCHEMBL1082192 0.80 EGLN3 (0.66) EGLN3EGLN1L3MBTL1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009134847-A1 PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2009-11-05 — — WO disclosed