Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.70 |
| ▸ | FBP1 | P09467 | 2/20 | 0.65 |
| ▸ | VCP | P55072 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15498134 | 0.89 | NFE2L2 (0.89) | NFE2L2TSHRCYP19A1FBP1VCP | |
| SCHEMBL27675542 | 0.85 | NFE2L2 (0.68) | NFE2L2TSHRACHECYP19A1FBP1 | |
| SCHEMBL11301074 | 0.85 | CYP19A1 (0.93) | NFE2L2TSHRCYP19A1FBP1VCP | |
| SCHEMBL11301072 | 0.85 | CYP19A1 (0.93) | NFE2L2TSHRCYP19A1FBP1VCP | |
| SCHEMBL1405312 | 0.84 | NFE2L2 (1.00) | NFE2L2TSHRCYP19A1FBP1VCP | |
| SCHEMBL1405314 | 0.84 | NFE2L2 (1.00) | NFE2L2TSHRCYP19A1FBP1VCP | |
| SCHEMBL8801662 | 0.83 | NFE2L2 (0.69) | NFE2L2TSHRACHECYP19A1FBP1 | |
| SCHEMBL92055 | 0.83 | TSHR (1.00) | NFE2L2TSHRACHEMAPTALDH1A1 | |
| SCHEMBL31183022 | 0.83 | TSHR (1.00) | NFE2L2TSHRACHEMAPTALDH1A1 | |
| SCHEMBL2486973 | 0.83 | TSHR (1.00) | NFE2L2TSHRACHEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | NFE2L2 3024/4885TSHR 1918/4885ACHE 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.