Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12267629 | 1.00 | HTRA1 (0.44) | HTRA1ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL12267627 | 0.90 | MMP2 (0.50) | HTRA1ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL3181312 | 0.88 | HDAC8 (0.44) | HTRA1ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL30229558 | 0.88 | HDAC8 (0.44) | HTRA1ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL3192635 | 0.88 | HDAC8 (0.44) | HTRA1ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL13481777 | 0.88 | HDAC8 (0.44) | HTRA1ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL2709313 | 0.85 | DPP4 (0.53) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL2709311 | 0.85 | DPP4 (0.53) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL2707643 | 0.83 | MMP2 (0.59) | HTRA1AGTR2MMP2USP30NR1H2 | |
| SCHEMBL2709145 | 0.83 | MMP2 (0.59) | HTRA1AGTR2MMP2USP30NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622496-B2 | antiarrhythmia agents; 1-(2-Amino-acetyl)-4-(benzoylamino)-pyrrolidine-2-carboxylic acid; desirable bioavailability properties | ZEALAND PHARMA A/S (DK) | 2009-11-24 | — | — | US | disclosed |