Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15886346 | 0.85 | TSHR (0.69) | POLBKMT2ATSHRHPGDKDM4E | |
| SCHEMBL10982179 | 0.85 | POLB (0.56) | POLBKMT2ATSHRHPGDUSP2 | |
| SCHEMBL7933600 | 0.83 | POLB (0.54) | POLBKMT2ATSHRHPGDKDM4E | |
| SCHEMBL4010685 | 0.83 | POLB (0.54) | POLBKMT2ATSHRHPGDLMNA | |
| SCHEMBL19879877 | 0.82 | ALDH1A1 (0.65) | POLBKMT2ATSHRHPGDLMNA | |
| SCHEMBL2755844 | 0.81 | ALDH1A1 (0.55) | POLBKMT2AUSP2ALOX15CASP1 | |
| SCHEMBL15886354 | 0.81 | ALDH1A1 (0.68) | POLBKMT2ATSHRHPGDLMNA | |
| SCHEMBL4101149 | 0.81 | KMT2A (0.56) | POLBKMT2ATSHRCASP7LMNA | |
| SCHEMBL1259319 | 0.80 | CYP1A2 (0.57) | POLBKMT2ATSHRHPGDHSD17B10 | |
| SCHEMBL12892664 | 0.80 | POLB (0.50) | POLBKMT2ATSHRHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |