Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 4/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.42 |
| ▸ | USP1 | O94782 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10130636 | 0.87 | LMNA (0.49) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL4178530 | 0.82 | LMNA (0.53) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL13514043 | 0.80 | LMNA (0.50) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL13625691 | 0.79 | LMNA (0.47) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL20372859 | 0.77 | LMNA (0.48) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL4183301 | 0.77 | LMNA (0.48) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL13699068 | 0.77 | LMNA (0.45) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL1599534 | 0.76 | LMNA (0.56) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL18338880 | 0.76 | LMNA (0.53) | LMNAKMT2AGRNSORT1CCNK | |
| SCHEMBL29691288 | 0.76 | LMNA (0.53) | LMNAKMT2AGRNSORT1CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137737-A2 | ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6, 11-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |