Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307294 | 0.88 | TRPM8 (0.37) | TP53MAPTTHRBSMN1; SMN2KLKB1 | |
| SCHEMBL10272262 | 0.79 | S1PR1 (0.34) | SMN1; SMN2TRPM8 | |
| SCHEMBL307375 | 0.78 | TRPM8 (0.39) | TP53MAPTTHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL307809 | 0.77 | TRPM8 (0.36) | TP53MAPTTHRBSMN1; SMN2LMNA | |
| SCHEMBL304906 | 0.77 | TRPM8 (0.38) | MAPTALDH1A1LMNATRPM8 | |
| SCHEMBL10223038 | 0.76 | TRPM8 (0.36) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL10223024 | 0.76 | TRPM8 (0.39) | MAPTALDH1A1LMNATRPM8 | |
| SCHEMBL10181751 | 0.75 | TRPM8 (0.38) | MAPTALDH1A1LMNATRPM8 | |
| SCHEMBL307103 | 0.74 | TRPM8 (0.38) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL10223034 | 0.73 | TRPM8 (0.38) | KDM4ETRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |