Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.55 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679690 | 0.89 | NPC1 (0.67) | NPC1RAB9ALMNATAAR1KMT2A | |
| SCHEMBL8420771 | 0.89 | NPC1 (0.67) | NPC1RAB9ALMNATAAR1KMT2A | |
| SCHEMBL4462033 | 0.89 | NPC1 (0.67) | NPC1RAB9ALMNATAAR1KMT2A | |
| SCHEMBL31545476 | 0.86 | NPC1 (0.63) | NPC1RAB9ALMNATAAR1ACACB | |
| SCHEMBL13624501 | 0.84 | SMN1; SMN2 (0.61) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL9183694 | 0.79 | NPC1 (0.63) | NPC1RAB9ALMNATAAR1KMT2A | |
| SCHEMBL24609344 | 0.79 | NPC1 (0.79) | NPC1RAB9ALMNATAAR1KMT2A | |
| SCHEMBL2543698 | 0.79 | NPC1 (0.79) | NPC1RAB9ALMNATAAR1KMT2A | |
| SCHEMBL14654946 | 0.79 | NPC1 (1.00) | NPC1RAB9ALMNATAAR1KMT2A | |
| Hydrochloric Acid SCHEMBL4323384 | 0.78 | NPC1 (0.76) | NPC1RAB9ALMNATAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |