Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20874537 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL13623898 | 0.84 | NPC1 (0.65) | SMN1; SMN2KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL2543476 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL3134592 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL10338537 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL10439543 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL10439379 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL3141208 | 0.78 | LMNA (0.58) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL10981741 | 0.78 | CTSK (0.62) | SMN1; SMN2KMT2AHPGDMEN1HTT | |
| SCHEMBL10974978 | 0.78 | CTSK (0.62) | SMN1; SMN2KMT2AHPGDMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |