Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Cocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 1.00 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 1.00 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cocaine SCHEMBL26609 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL8440314 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL21931 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL16922143 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL5991910 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL23086019 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL20390951 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL10066803 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL21189582 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL21930 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141627-A1 | TREATING NIEMANN-PICK DISEASE TYPE C AND RELATED DISORDERS BY ELEVATING INTRACELLULAR CALCIUM | ISIS INNOVATION LIMITED (GB) | 2009-11-26 | — | — | WO | disclosed |