Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Cocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 1.00 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 1.00 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cocaine SCHEMBL26609 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL8440314 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL16922143 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL13624557 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL5991910 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL23086019 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL20390951 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL10066803 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL21189582 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT | |
| Cocaine SCHEMBL21930 | 1.00 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 89010 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144801-A1 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144773-A1 | METHODS OF REDUCING PHYSICAL DEPENDENCE TO NEUROPSYCHIATRIC TREATMENTS | SUMITOMO PHARMA AMERICA, INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747639-A2 | BETA-GALACTOSIDASE ENZYME-BASED IMMUNOASSAY | Abbott Diagnostics Scarborough, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122081274-A | Cocaine esterase multi-site mutant, protein dimer thereof and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075410-A | Dry powder composition for intranasal delivery | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| US-12637612-B2 | Fluorescent opioid binding compound and uses thereof | GEORGE MASON UNIVERSITY | 2026-05-26 | — | — | US | claimed |
| US-20260139032-A1 | ACTIVIN RECEPTOR TYPE IIB VARIANTS AND USES THEREOF | 35PHARMA INC (CA) | 2026-05-21 | — | — | US | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| WO-2026106499-A1 | OREXIN RECEPTOR ANTAGONISTS: 2-AZABICYCLIC COMPOUNDS | BIAL - PORTELA & CA., S.A. (PT) | 2026-05-21 | — | — | WO | claimed |
| US-4353886-A | DETECTION OF NARCOTIC VAPORS BY COMPLEXING WITH ANTIBODY | IRT CORPORATION (US) | 1982-10-12 | — | — | US | claimed |
| US-4320086-A | Paper device for rapid detection of cocaine | REISS ANDRE | 1982-03-16 | — | — | US | claimed |
| US-4260517-A | Available aroma of cocaine | WOODFORD WARREN J | 1981-04-07 | — | — | US | claimed |
| US-4248855-A | SALT FORMING NITROGEN COMPOUND AND A POLYMER CONTAINING AN ACID GROUP FOR FORMING A SUSTAINED RELEASE COMPOSITION | HYDROPHILICS INTERNATIONAL, INC. (US) | 1981-02-03 | — | — | US | claimed |
| US-4235864-A | Simultaneous radio immunoassay of multiple antigens and _assay for cocaine metabolites | RESEARCH CORPORATION (US) | 1980-11-25 | — | — | US | claimed |
| US-4207307-A | Simultaneous immunoassay of multiple antigens and assay for cocaine metabolites | RESEARCH CORPORATION (US) | 1980-06-10 | — | — | US | claimed |
| US-4110078-A | CHLOROPLATINIC ACID, COBALTOUS THIOCYANATE, HYDROCARBON LIQUID | ZELONIS PAUL THOMAS | 1978-08-29 | — | — | US | claimed |
| US-4104029-A | CHEMILUMINESCENT LABELING | MAIER JR CHARLES L | 1978-08-01 | — | — | US | claimed |
| US-4102979-A | IODINE LABEL, COCAINE | HOFFMANN-LA ROCHE INC. (US) | 1978-07-25 | — | — | US | claimed |
| US-4022878-A | NATIVE HOMOLOGOUS HAPTEN OR ANTIGEN | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-05-10 | — | — | US | claimed |