Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2627328 | 0.84 | NFKB1 (0.43) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL24818982 | 0.78 | GAA (0.51) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL764580 | 0.78 | GAA (0.51) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL15192054 | 0.78 | GAA (0.51) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL765253 | 0.77 | BTK (0.53) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL1988919 | 0.77 | NFKB1 (0.54) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL12649367 | 0.77 | BTK (0.57) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL19773841 | 0.77 | BTK (0.53) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL24062392 | 0.77 | BTK (0.57) | NFKB1NFKB2RELABTKGAA | |
| SCHEMBL12885089 | 0.77 | BTK (0.53) | NFKB1NFKB2RELABTKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |