Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2220909 | 0.85 | LIMK1 (0.46) | BRD4RAB9AKDM4EL3MBTL1HPGD | |
| SCHEMBL2950634 | 0.83 | KDM4E (0.60) | RAB9AKDM4EL3MBTL1HPGDTSHR | |
| SCHEMBL19587047 | 0.73 | LMNA (0.46) | RAB9AKDM4EL3MBTL1TSHRHSD17B10 | |
| SCHEMBL21283315 | 0.73 | KDM4E (0.34) | RAB9AKDM4EL3MBTL1HPGDTSHR | |
| SCHEMBL30168106 | 0.73 | KDM4E (0.68) | RAB9AKDM4EHPGDTSHRALDH1A1 | |
| SCHEMBL6857835 | 0.73 | KDM4E (0.68) | RAB9AKDM4EHPGDTSHRALDH1A1 | |
| SCHEMBL4140971 | 0.72 | EDNRA (0.49) | BRD4RAB9AKDM4EL3MBTL1HPGD | |
| SCHEMBL2946788 | 0.71 | SMN1; SMN2 (0.58) | BRD4RAB9AKDM4EL3MBTL1HPGD | |
| SCHEMBL13925859 | 0.71 | KDM4E (0.40) | BRD4RAB9AKDM4EL3MBTL1HPGD | |
| SCHEMBL9693742 | 0.70 | TSHR (0.45) | BRD4RAB9AKDM4EL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | NR2C2, CYP4B1, OXER1 | BRD4 710/4885RAB9A 3809/4885KDM4E 3819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.