Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11648412 | 0.86 | MAPT (0.74) | CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11647122 | 0.82 | MAPT (0.69) | CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11651372 | 0.81 | MAPT (0.68) | CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL3806017 | 0.81 | MEN1 (0.73) | CYP3A4CYP1A2CYP2D6L3MBTL1MEN1 | |
| Glutarate SCHEMBL9316643 | 0.81 | NPC1 (0.53) | CYP3A4CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL14431137 | 0.79 | HSD17B10 (0.62) | CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6399270 | 0.78 | HSD17B10 (0.53) | CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11672644 | 0.77 | CA1 (0.68) | L3MBTL1ABATMEN1KMT2AMAPT | |
| SCHEMBL1060805 | 0.77 | HDAC4 (0.73) | CYP3A4CYP1A2CYP2D6L3MBTL1MEN1 | |
| SCHEMBL13997215 | 0.76 | L3MBTL1 (0.59) | CYP3A4L3MBTL1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406870-B1 | TAXOL ENHANCER COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2009-11-11 | — | — | EP | disclosed |
| US-7435843-B2 | Synthesis of taxol enhancers | SYNTA PHARMACEUTICALS CORP. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435843-B2 | Synthesis of taxol enhancers | SYNTA PHARMACEUTICALS CORP. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7368473-B2 | Paclitaxel enhancer compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368473-B2 | Paclitaxel enhancer compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2008-05-06 | — | — | US | disclosed |