Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736259 | 0.92 | HSD11B1 (0.80) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL957990 | 0.92 | HSD11B1 (0.80) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL957992 | 0.92 | HSD11B1 (0.80) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL960127 | 0.89 | HSD11B1 (0.80) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL960124 | 0.89 | HSD11B1 (0.80) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL960126 | 0.89 | HSD11B1 (0.80) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL957557 | 0.88 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15959057 | 0.88 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL957558 | 0.88 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13552277 | 0.88 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |