Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734950 | 0.88 | SMN1; SMN2 (0.33) | SMN1; SMN2HTR1AMEN1KMT2ANPSR1 | |
| SCHEMBL2698655 | 0.88 | SMN1; SMN2 (0.33) | SMN1; SMN2HTR1AMEN1KMT2ANPSR1 | |
| SCHEMBL13552219 | 0.88 | CYP3A4 (0.32) | SMN1; SMN2HTR1AMEN1KMT2ANPSR1 | |
| SCHEMBL13624936 | 0.81 | SMN1; SMN2 (0.35) | SMN1; SMN2HTR1AHTR7HTR6MEN1 | |
| SCHEMBL13552217 | 0.76 | HTR1A (0.37) | SMN1; SMN2HTR1AHTR7HTR6MEN1 | |
| SCHEMBL5478444 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2HTR1AHTR7HTR6MEN1 | |
| SCHEMBL5478440 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2HTR1AHTR7HTR6MEN1 | |
| SCHEMBL117417 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2HTR1AMEN1KMT2ANPSR1 | |
| SCHEMBL956973 | 0.69 | SMN1; SMN2 (0.33) | SMN1; SMN2HTR1AMEN1KMT2ANPSR1 | |
| SCHEMBL118814 | 0.69 | SMN1; SMN2 (0.33) | SMN1; SMN2HTR1AMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |