Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510908 | 0.84 | KDM4E (0.53) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL571602 | 0.83 | KDM4E (0.63) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL2770506 | 0.81 | KDM4E (0.65) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL9245905 | 0.81 | KDM4E (0.57) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL14446357 | 0.81 | KDM4E (0.51) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL26920799 | 0.81 | KMT2A (0.50) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL27466936 | 0.81 | KDM4E (0.67) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL3454271 | 0.79 | KDM4E (0.55) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL30112294 | 0.79 | KDM4E (0.55) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL168947 | 0.79 | KDM4E (0.62) | KDM4ECYP3A4ALOX12TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619091-B2 | Treating nervous system disorders such as mild cognitive impairment, Alzheimer's disease or dementia associated with Down syndrome; e.g. use of 5,7-dichloro-8-hydroxy-2-(2-pyridyl)-quinoline (PBT 1052) | PRANA BIOTECHNOLOGY LIMITED (AU) | 2009-11-17 | — | — | US | disclosed |