Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625182 | 0.83 | FGFR1 (0.33) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL10118030 | 0.81 | FGFR1 (0.38) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL13625183 | 0.78 | FGFR1 (0.42) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL279415 | 0.76 | FGFR1 (0.39) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL10135535 | 0.75 | ACVRL1 (0.31) | ACVRL1 | |
| SCHEMBL13625180 | 0.75 | FGFR1 (0.55) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL10118032 | 0.71 | RET (0.37) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL279494 | 0.71 | FGFR1 (0.37) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL279456 | 0.71 | FGFR1 (0.34) | FGFR1FGFR3KDRPLK4AURKA | |
| SCHEMBL279744 | 0.69 | FGFR1 (0.40) | FGFR1FGFR3KDRPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136966-A1 | INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2009-11-12 | — | — | WO | disclosed |