Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400681 | 0.90 | POLB (0.46) | POLBALDH1A1HPGDMAPTHDAC3 | |
| SCHEMBL13643864 | 0.89 | POLB (0.47) | POLBALDH1A1HPGDMAPTLMNA | |
| SCHEMBL16404365 | 0.89 | POLB (0.45) | POLBALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13625396 | 0.89 | POLB (0.47) | POLBALDH1A1HPGDMAPTLMNA | |
| SCHEMBL14297023 | 0.88 | ALDH1A1 (0.57) | POLBALDH1A1HPGDMAPTLMNA | |
| SCHEMBL14297024 | 0.87 | POLB (0.47) | POLBALDH1A1HPGDMAPTLMNA | |
| SCHEMBL14297017 | 0.87 | POLB (0.48) | POLBALDH1A1HPGDMAPTHDAC3 | |
| SCHEMBL13471912 | 0.86 | POLB (0.44) | POLBALDH1A1HPGDMAPTLMNA | |
| SCHEMBL16425205 | 0.86 | HPGD (0.50) | POLBALDH1A1HPGDLMNAHDAC3 | |
| SCHEMBL14297027 | 0.86 | POLB (0.43) | POLBALDH1A1HPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9352050-B2 | Processes for preparing peptide conjugates and linkers | PFIZER INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150031108-A1 | PROCESSES FOR PREPARING PEPTIDE CONJUGATES AND LINKERS | PEPTIDE LOGIC LLC | 2015-01-29 | — | — | US | disclosed |
| US-20120321591-A1 | ANTI-ANGIOGENIC COMPOUNDS | COVX TECHNOLOGIES IRELAND, LIMITED | 2012-12-20 | — | — | US | disclosed |
| WO-2009136352-A1 | ANTI-ANGIOGENIC COMPOUNDS | COVX TECHNOLOGIES IRELAND, LTD. (IE) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120321591-A1 | ANTI-ANGIOGENIC COMPOUNDS | VEGFA, FLT4, FLT1 | POLB 1606/4885ALDH1A1 2557/4885HPGD 2530/4885 |
| US-20150031108-A1 | PROCESSES FOR PREPARING PEPTIDE CONJUGATES AND LINKERS | VIP, NGLY1, PTMS | POLB 2892/4885ALDH1A1 3137/4885HPGD 2730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.