Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321688 | 0.88 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL12837212 | 0.88 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL1518297 | 0.88 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL1518294 | 0.88 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL1518300 | 0.88 | REN (1.00) | RENKCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1073450 | 0.87 | REN (0.99) | RENKCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1073452 | 0.87 | REN (0.99) | RENKCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1518532 | 0.87 | REN (0.99) | RENKCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1518626 | 0.87 | REN (0.99) | RENKCNH2CYP3A4 | |
| SCHEMBL13625855 | 0.83 | REN (0.71) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |