Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | REN | P00797 | 11/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625719 | 0.81 | REN (0.60) | RENKCNH2CYP3A4 | |
| SCHEMBL663581 | 0.81 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3RENKCNH2 | |
| SCHEMBL24872977 | 0.79 | REN (0.57) | SLC6A4SLC6A2SLC6A3RENKCNH2 | |
| SCHEMBL31258379 | 0.78 | REN (0.58) | SLC6A4SLC6A2SLC6A3RENKCNH2 | |
| SCHEMBL13625716 | 0.76 | REN (0.58) | RENKCNH2CYP3A4 | |
| SCHEMBL13625723 | 0.74 | REN (0.58) | SLC6A4SLC6A2RENKCNH2CYP3A4 | |
| SCHEMBL13617898 | 0.72 | REN (0.54) | SLC6A4SLC6A2SLC6A3RENKCNH2 | |
| SCHEMBL662637 | 0.71 | REN (0.47) | SLC6A4SLC6A2SLC6A3RENKCNH2 | |
| SCHEMBL12837153 | 0.71 | REN (0.80) | RENKCNH2CYP3A4 | |
| SCHEMBL1518267 | 0.71 | REN (0.80) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |