Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | FSHR | P23945 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2388490 | 1.00 | LMNA (0.42) | LMNASMN1; SMN2MEN1KMT2AALOX15 | |
| SCHEMBL8989907 | 0.96 | LMNA (0.39) | LMNASMN1; SMN2MEN1KMT2AALOX15 | |
| SCHEMBL8988339 | 0.96 | LMNA (0.39) | LMNASMN1; SMN2MEN1KMT2AALOX15 | |
| SCHEMBL11973314 | 0.88 | S1PR2 (0.37) | LMNASMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL11973796 | 0.88 | TP53 (0.38) | SMN1; SMN2HTTS1PR2TSHROPRM1 | |
| SCHEMBL8988202 | 0.88 | FSHR (0.44) | SMN1; SMN2MEN1KMT2ATSHRFSHR | |
| SCHEMBL2389637 | 0.88 | FSHR (0.44) | SMN1; SMN2MEN1KMT2ATSHRFSHR | |
| SCHEMBL2392497 | 0.88 | FSHR (0.44) | SMN1; SMN2MEN1KMT2ATSHRFSHR | |
| SCHEMBL14899278 | 0.86 | LMNA (0.35) | LMNASMN1; SMN2MEN1KMT2AALOX15 | |
| SCHEMBL14899279 | 0.86 | HIF1A (0.39) | MEN1KMT2AHSD17B10S1PR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431702-B2 | Therapeutically useful substituted hydropyrido [3,2,1-ij] quinoline compounds | ALLERGAN, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| WO-2009137681-A1 | THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-IJ] QUINOLINE COMPOUNDS | ALLERGAN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |