Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 4/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626250 | 1.00 | ADRB2 (0.47) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL13625786 | 1.00 | ADRB2 (0.47) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL144925 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL144356 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL143930 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL144893 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL143670 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL146240 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL140444 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 | |
| SCHEMBL139825 | 0.87 | ADRB2 (0.44) | ADRB2TOP2ATOP2BSTAT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |