Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391384 | 0.83 | DRD1 (0.43) | IGF1RALOX15DRD1 | |
| SCHEMBL13625662 | 0.81 | MAPT (0.43) | LMNACYP3A4IDO1IGF1RALOX15 | |
| SCHEMBL8989689 | 0.79 | SMN1; SMN2 (0.45) | LMNA | |
| SCHEMBL14523185 | 0.79 | SCN9A (0.43) | LMNA | |
| SCHEMBL4347105 | 0.79 | EEF2K (0.43) | — | |
| SCHEMBL2391310 | 0.77 | HTT (0.40) | LMNA | |
| SCHEMBL11997214 | 0.77 | ALDH1A1 (0.35) | IGF1RALOX15DRD1 | |
| SCHEMBL1411683 | 0.76 | KDM4E (0.39) | LMNA | |
| SCHEMBL8988943 | 0.76 | MAPT (0.39) | LMNA | |
| SCHEMBL13619991 | 0.76 | NPC1 (0.48) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137342-A1 | THERAPEUTICALLY USEFUL SUBSTITUTED 1, 7-DIPHENYL-L, 2, 3, 5, 6, 7-HEXAHYDROPYRIDO [ 3, 2, 1-I J ] QUINOLINE COMPOUNDS | ALLERGAN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |