Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.45 |
| ▸ | FGR | P09769 | 1/20 | 0.45 |
| ▸ | TEC | P42680 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626373 | 0.89 | BTK (0.41) | BTKFGRTECBMX | |
| SCHEMBL13626132 | 0.89 | BTK (0.50) | BTKYES1FGRTECBMX | |
| SCHEMBL13626138 | 0.89 | BTK (0.51) | BTKYES1FGRTECBMX | |
| SCHEMBL13626182 | 0.88 | BTK (0.48) | BTKYES1FGRTECBMX | |
| SCHEMBL13626372 | 0.85 | CCND1 (0.46) | BTKYES1FGRTECBMX | |
| SCHEMBL1423616 | 0.82 | BTK (0.54) | BTKYES1FGRTECBMX | |
| SCHEMBL13626829 | 0.80 | BTK (0.55) | BTK | |
| SCHEMBL13626127 | 0.80 | CCND1 (0.43) | BTKYES1FGRTECBMX | |
| SCHEMBL1423256 | 0.76 | BTK (0.49) | BTKYES1FGRTECBMX | |
| SCHEMBL13626122 | 0.75 | BTK (0.55) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |