Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 18/20 | 0.38 |
| ▸ | FGR | P09769 | 2/20 | 0.36 |
| ▸ | TEC | P42680 | 2/20 | 0.36 |
| ▸ | BMX | P51813 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626127 | 0.94 | CCND1 (0.43) | CCND1CDK6BTKFGRTEC | |
| SCHEMBL13626377 | 0.89 | CDK6 (0.45) | CCND1CDK6BTKFGRTEC | |
| SCHEMBL13626823 | 0.89 | CCND1 (0.40) | CCND1CDK6BTKCDK4 | |
| SCHEMBL13626378 | 0.89 | CCND1 (0.47) | CCND1CDK6BTKFGRTEC | |
| SCHEMBL13626188 | 0.87 | CDK6 (0.45) | CCND1CDK6BTKFGRTEC | |
| SCHEMBL13626142 | 0.85 | BTK (0.54) | BTKFGRTECBMXYES1 | |
| SCHEMBL1422829 | 0.84 | CCND1 (0.40) | CCND1CDK6BTKFGRTEC | |
| SCHEMBL1422539 | 0.78 | BTK (0.39) | CCND1CDK6BTKFGRTEC | |
| SCHEMBL13626373 | 0.75 | BTK (0.41) | BTKFGRTECBMXSRC | |
| SCHEMBL13626138 | 0.74 | BTK (0.51) | BTKFGRTECBMXYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |