Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.39 |
| ▸ | NR1D2 | Q14995 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12666567 | 0.83 | HDAC4 (0.50) | HDAC4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL13626300 | 0.76 | POLB (0.61) | HDAC4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11692509 | 0.75 | POLB (0.60) | HDAC4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4692536 | 0.74 | HDAC4 (0.42) | HDAC4POLBALDH1A1CYP2C19 | |
| SCHEMBL24015917 | 0.73 | POLB (0.37) | HDAC3HDAC1HDAC2HDAC6POLB | |
| SCHEMBL20738594 | 0.73 | POLB (0.61) | HDAC4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4942997 | 0.72 | HDAC4 (0.64) | HDAC4ALDH1A1GAA | |
| SCHEMBL23647373 | 0.72 | HDAC4 (0.44) | HDAC4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4686984 | 0.72 | HDAC4 (0.40) | HDAC4POLBALDH1A1CYP2C19 | |
| SCHEMBL6233265 | 0.71 | POLB (0.52) | HDAC1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | disclosed |