Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 2/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626300 | 0.90 | POLB (0.61) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11692509 | 0.88 | POLB (0.60) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL20738594 | 0.86 | POLB (0.61) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5987740 | 0.83 | POLB (0.65) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2362049 | 0.80 | TACR3 (0.44) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6560911 | 0.79 | POLB (0.43) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8351047 | 0.78 | POLB (0.46) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9931507 | 0.77 | POLB (0.44) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3560390 | 0.75 | SSTR4 (0.56) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2231946 | 0.75 | POLB (0.57) | POLBALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507763-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097607-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |