Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779676 | 0.84 | HDAC1 (0.59) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL26849762 | 0.83 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1779536 | 0.80 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL15503805 | 0.78 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL31050852 | 0.77 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL28984081 | 0.77 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL29348766 | 0.75 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL29531380 | 0.74 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL12437777 | 0.74 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL4834485 | 0.74 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | disclosed |