Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.56 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626552 | 0.90 | F10 (0.61) | F10CFTR | |
| SCHEMBL13626553 | 0.90 | F10 (0.61) | F10CFTR | |
| SCHEMBL13626567 | 0.83 | F10 (0.52) | F10CFTRLMNAPKM | |
| SCHEMBL4604418 | 0.83 | F10 (0.78) | F10 | |
| SCHEMBL4605676 | 0.83 | F10 (0.76) | F10 | |
| SCHEMBL4606847 | 0.83 | F10 (0.78) | F10 | |
| SCHEMBL13626556 | 0.82 | F10 (0.55) | F10CFTR | |
| SCHEMBL5537707 | 0.81 | F10 (0.66) | F10 | |
| SCHEMBL3097010 | 0.76 | F10 (0.47) | F10LMNAPKM | |
| SCHEMBL3096992 | 0.76 | F10 (0.47) | F10LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |