Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 10/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626908 | 0.96 | FGFR3 (0.40) | FGFR3HPGDSPDE10AFGFR4CRHR1 | |
| SCHEMBL1126531 | 0.89 | FGFR3 (0.40) | FGFR3HPGDSPDE10AFGFR4CRHR1 | |
| SCHEMBL3315714 | 0.85 | HPGDS (0.40) | FGFR3HPGDSFGFR4KDM4ESRC | |
| SCHEMBL1126110 | 0.85 | FGFR3 (0.40) | FGFR3HPGDSPDE10AFGFR4KDM4E | |
| SCHEMBL1126188 | 0.84 | FGFR3 (0.38) | FGFR3HPGDSFGFR4CRHR1KDM4E | |
| SCHEMBL14212756 | 0.83 | FGFR3 (0.36) | FGFR3HPGDSPDE10AFGFR4CRHR1 | |
| SCHEMBL1126329 | 0.82 | FGFR3 (0.59) | FGFR3FGFR4SRC | |
| SCHEMBL1126157 | 0.80 | FGFR3 (0.38) | FGFR3HPGDSFGFR4 | |
| SCHEMBL1126172 | 0.80 | FGFR3 (0.38) | FGFR3HPGDSFGFR4CRHR1 | |
| SCHEMBL1126250 | 0.80 | FGFR3 (0.37) | FGFR3HPGDSFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |