Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17772313 | 0.92 | DRD4 (0.46) | DRD4EPHX2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL12880950 | 0.87 | PARP1 (0.50) | DRD4SMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL1035236 | 0.84 | MAPT (0.50) | DRD4EPHX2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1034071 | 0.81 | CNR2 (0.49) | DRD4MAPTMAP4K4GPR52KDM1A | |
| SCHEMBL1032826 | 0.81 | POLB (0.45) | DRD4MAPTJAK2MAP4K4KDM1A | |
| SCHEMBL1033395 | 0.78 | HDAC4 (0.46) | DRD4MAP4K4MEN1KMT2A | |
| SCHEMBL1033396 | 0.78 | HDAC4 (0.46) | DRD4MAP4K4MEN1KMT2A | |
| SCHEMBL1032402 | 0.77 | CHRNA7 (0.52) | — | |
| SCHEMBL1034785 | 0.74 | SCN7A (0.42) | DRD4MAP4K4GPR52KDM1A | |
| SCHEMBL4602598 | 0.73 | EPHX2 (0.60) | DRD4EPHX2PHGDHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134973-A1 | QUENOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |