Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | MET | P08581 | 9/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891719 | 0.90 | PDGFRA (0.60) | PDGFRAKDRMETAXL | |
| SCHEMBL1897599 | 0.89 | KDR (0.49) | PDGFRAKDRMETAXLFLT3 | |
| SCHEMBL13627580 | 0.89 | PDGFRA (0.51) | PDGFRAKDRMETAXLFLT3 | |
| SCHEMBL12673766 | 0.82 | KDR (0.61) | PDGFRAKDR | |
| SCHEMBL1893098 | 0.82 | KDR (0.60) | PDGFRAKDR | |
| SCHEMBL1893240 | 0.82 | KDR (0.60) | PDGFRAKDR | |
| SCHEMBL1893004 | 0.81 | PDGFRA (0.59) | PDGFRAKDRMETAXL | |
| SCHEMBL14693163 | 0.81 | PDGFRA (0.58) | PDGFRAKDR | |
| SCHEMBL1888598 | 0.80 | KDR (0.60) | PDGFRAKDRMETAXLRET | |
| SCHEMBL12664002 | 0.79 | KDR (0.44) | PDGFRAKDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |