Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | MET | P08581 | 11/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894791 | 0.90 | PDGFRA (0.61) | PDGFRAKDRMETAXLRET | |
| SCHEMBL12411845 | 0.89 | KDR (0.50) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL13627231 | 0.89 | PDGFRA (0.50) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1891121 | 0.89 | KDR (0.51) | PDGFRAKDRMETAXLHDAC1 | |
| SCHEMBL1893428 | 0.82 | KDR (0.51) | PDGFRAKDRMETAXLRET | |
| SCHEMBL1898468 | 0.82 | PDGFRA (0.59) | PDGFRAKDRMETAXL | |
| SCHEMBL1897126 | 0.81 | KDR (0.61) | PDGFRAKDRMETHDAC1 | |
| SCHEMBL1897152 | 0.81 | KDR (0.60) | PDGFRAKDRMET | |
| SCHEMBL1890686 | 0.80 | MET (0.44) | PDGFRAKDRMETAXLPDGFRB | |
| SCHEMBL12663982 | 0.79 | KDR (0.45) | PDGFRAKDRMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |