Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399620 | 1.00 | CHRNB4 (0.41) | CHRNB4CHRNA3HTR2CHTR2AHTR2B | |
| SCHEMBL14411860 | 0.94 | CHRNB4 (0.42) | CHRNB4CHRNA3HTR2CHTR2AHTR2B | |
| SCHEMBL1804494 | 0.84 | CHRNB4 (0.37) | CHRNB4CHRNA3HTR2CHTR2AHTR2B | |
| SCHEMBL1804493 | 0.84 | CHRNB4 (0.37) | CHRNB4CHRNA3HTR2CHTR2AHTR2B | |
| SCHEMBL1804490 | 0.84 | CHRNB4 (0.37) | CHRNB4CHRNA3HTR2CHTR2AHTR2B | |
| SCHEMBL24138192 | 0.80 | CHRNB4 (0.39) | CHRNB4CHRNA3HTR2CHTR2BCHRNB2 | |
| SCHEMBL19696035 | 0.80 | CHRNB4 (0.39) | CHRNB4CHRNA3HTR2CHTR2BCHRNB2 | |
| SCHEMBL19122664 | 0.80 | CHRNB4 (0.39) | CHRNB4CHRNA3HTR2CHTR2BCHRNB2 | |
| SCHEMBL30417082 | 0.79 | CHRNB4 (0.39) | CHRNB4CHRNA3 | |
| SCHEMBL18925342 | 0.78 | MEN1 (0.35) | CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |