Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | CCKBR | P32239 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750781 | 1.00 | MEN1 (0.35) | MEN1GAAKMT2ACHRNB4CHRNA3 | |
| SCHEMBL8266212 | 0.89 | AR (0.40) | MEN1GAAKMT2ANOS2AR | |
| SCHEMBL13438556 | 0.89 | AR (0.40) | MEN1GAAKMT2ANOS2AR | |
| SCHEMBL3600208 | 0.89 | AR (0.40) | MEN1GAAKMT2ANOS2AR | |
| SCHEMBL7252266 | 0.89 | LMNA (0.41) | MEN1GAAKMT2ANOS2AR | |
| SCHEMBL5661864 | 0.89 | AR (0.40) | MEN1GAAKMT2ANOS2AR | |
| SCHEMBL24138192 | 0.82 | CHRNB4 (0.39) | MEN1GAAKMT2ACHRNB4CHRNA3 | |
| SCHEMBL19696035 | 0.82 | CHRNB4 (0.39) | MEN1GAAKMT2ACHRNB4CHRNA3 | |
| SCHEMBL19122664 | 0.82 | CHRNB4 (0.39) | MEN1GAAKMT2ACHRNB4CHRNA3 | |
| SCHEMBL30417082 | 0.81 | CHRNB4 (0.39) | MEN1GAAKMT2ACHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |