Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241281 | 1.00 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL4478604 | 1.00 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL4493049 | 1.00 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL13627350 | 0.94 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL13627351 | 0.94 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL4485116 | 0.94 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL13637322 | 0.94 | IDO1 (0.41) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL11523893 | 0.86 | HTR2C (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL6137734 | 0.83 | IDO1 (0.45) | IDO1ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL4763337 | 0.83 | IDO1 (0.45) | IDO1ALDH1A1MAPTL3MBTL1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |