Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138514 | 0.76 | POLB (0.43) | L3MBTL1ALDH1A1GAAPOLBMAPT | |
| SCHEMBL4594309 | 0.74 | ALDH1A1 (0.40) | ALDH1A1GAAPOLBTDP1KDM4E | |
| SCHEMBL24553583 | 0.71 | NPC1 (0.35) | L3MBTL1ALDH1A1GAAPOLBMAPT | |
| SCHEMBL13627354 | 0.71 | ADORA2A (0.32) | — | |
| SCHEMBL27895789 | 0.71 | HCAR2 (0.38) | L3MBTL1ALDH1A1GAAPOLBMAPT | |
| SCHEMBL31467465 | 0.69 | HCAR2 (0.43) | ALDH1A1GAAKDM4EHCAR2NPC1 | |
| SCHEMBL15569843 | 0.67 | MAPT (0.34) | L3MBTL1ALDH1A1GAAPOLBMAPT | |
| SCHEMBL22890374 | 0.67 | KDM4E (0.43) | L3MBTL1ALDH1A1GAAKDM4EHCAR2 | |
| SCHEMBL24553750 | 0.65 | MEN1 (0.35) | ALDH1A1GAAMAPTKDM4ENPC1 | |
| SCHEMBL30988460 | 0.64 | GRM5 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622471-B2 | Pyrazole derivatives having a pyridazine and pyridine functionality | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-11-24 | — | — | US | disclosed |